AKOSKY MINDLIGHT, the natural stress reliever Active with fresh Alfalfa Sprouts, that prevents skin aging and skin damage typical of stressed skin

Time: 3:10 pm - 3:30 pm

Date: 15 November

Theatre: Room C

15-11-2023 15:10 15-11-2023 15:30 Europe/London AKOSKY MINDLIGHT, the natural stress reliever Active with fresh Alfalfa Sprouts, that prevents skin aging and skin damage typical of stressed skin

Psychological stress has negative effects on healthy skin affecting its integrity and function. This is due to the activation of the central and peripheral cutaneous hypothalamic-pituitary-adrenal (HPA) axis, including the 11β-HSD1 enzyme that catalyzed the conversion from inactive cortisone to active cortisol in skin cells. AKOSKYTM MINDLIGHT was able to act on cortisol biosynthesis and… Read more »

SCS Formulate

Psychological stress has negative effects on healthy skin affecting its integrity and function.

This is due to the activation of the central and peripheral cutaneous hypothalamic-pituitary-adrenal (HPA) axis, including the 11β-HSD1 enzyme that catalyzed the conversion from inactive cortisone to active cortisol in skin cells.

AKOSKYTM MINDLIGHT was able to act on cortisol biosynthesis and fibroblast stiffness consequently reducing skin aging and skin damage induced by psychological stress.

The effect of AKOSKYTM MINDLIGHT (lyophilized) active was investigated in vitro, evaluating its cell proliferative effects and impact on cortisol biosynthesis associated with the inhibition of the 11β-HSD1 enzyme. In addition, mechanical properties analysis was realized in cell culture treated with the active ingredient and cortisol. To assess it, it is performed an Atomic Force Microscope measurement to obtain information about the mechanical properties of primary fibroblasts from a 30-year-old donor, both in the nucleus and the cytoplasm area to also obtain information about the global fibroblast stiffness.

Moreover, AKOSKYTM MINDLIGHT was clinically tested on a stressed population to observe its efficacy in improving the expression wrinkles, skin mechanical properties, skin barrier, skin redness, and skin radiance.

Globally, this innovative study demonstrated, for the first time in the cosmetic field, that cortisol has a negative impact on fibroblast mechanical properties, causing its increase in stiffness, and consequently, premature aging, and AKOSKYTM MINDLIGHT both inhibits cortisol biosynthesis and decreases fibroblast stiffness.

Accordingly, AKOSKYTM MINDLIGHT, an active ingredient based on Medicago Sativa sprouts, showed to reduce the unwanted effects of stress on the skin of individuals.

Speakers

  • Antonio Ciavola General Manager - Akott Evolution

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