Timeless Beauty

Geroscience showed that by targeting specific biological hallmarks, longevity extension is possible. Despite numerous studies, solutions are still needed to extend skin longevity. The objective here is to fill this gap and develop a natural active able to extend skin healthspan. Schisandrins are lignans acting on longevity hallmarks. An active enriched in these was developed from Schisandra chinensis berries. In vitro results showed that Schisandra extract (SchE) significantly increases longevity genes expression, autophagy and mitochondrial markers. In stressed 3D models, SchE restores skin barrier, reduces oxidation and inflammation. Clinically vs. placebo on multi-ethnic panels, SchE significantly increases skin microcirculation, elasticity and brightness and prevents wrinkles. As longevity is the result of the optimal functioning of interconnected biological activities, thanks to its multi-action on these, SchE is a potent solution to extend skin healthspan for a timeless beauty.