Microbiome and Quorum Sensing communication in skin health

Time: 4:00 pm - 4:30 pm

Date: 12 November

The human skin microbiome plays a key role in maintaining a healthy skin. This microbiome is made of complex microbial communities which live on the skin and which assemble into biofilms. Biofilms are ubiquitous and present not only in different areas of our bodies but also in the outside environment. At the National Biofilms Innovation Centre (NBIC), in partnership with industry, we are developing novel strategies to prevent, detect, manage and engineer biofilms. Microbes living in these biofilm communities communicate using small chemicals known as quorum sensing (QS) signals. These signals play an important role in the interaction between the microbiome and the host as well are being key switches for the production of toxic products by some microorganisms which can damage the host.  We are designing strategies to interfere with QS signalling as a way to reduce or inhibit the damage caused by some microbes which will result in the regeneration of a healthy microbiome ultimately having a positive impact on the host including the maintenance of a healthy skin.


Learning Outcomes
This presentation will be addressing the following:

  • Understanding Biofilms: What is a biofilm and its relevance to the skin microbiome.

  • Microbial communication in the microbiome
    : How bacteria can use quorum sensing (QS) as a way to communicate with each other in biofilms.

  • Microbiome interaction with the host
    : How QS molecules used by bacteria to interact with each other can also affect several aspects of human health and by extrapolation skin health.

  • Interfering with bacterial communication
    : Strategies used to interfere with signalling in the microbiome to promote health including that of skin.


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